Plumbaginales belongs to the superorder Malviflorae and comprises two families, Plumbaginaceae and Limoniaceae. Its representatives are chemically characterized by the presence of naphthoquinones, flavonoids, terpenoids and steroids, many of them being the responsible for biodynamic activities. The extracts of some species of Plumbaginales and also some isolated compounds revealed to be of great importance in the search of new drugs, since they have been described in literature for the treatment of many diseases such as: leishmaniasis, Chagas´ disease, malaria, cancer and others. Plants represent a valuable source of bioactive compounds and should be investigated, as a promise in the development of effective, ready available and lesscostly drugs